Serum C1q and tumor necrosis factor (TNF)-related protein 9 in women with Polycystic Ovary Syndrome

•Although, CTRP9 (C1q and tumor necrosis factor (TNF)-related protein 9) levels are higher in PCOS patients as compared to their age and BMI-matched controls, this finding fails to be statistically significant.•Serum concentrations of CTRP9 positively correlate with serum LDL-C and total cholesterol in PCOS group.•There is a weak association between CTRP9 and TG.

AimsTo compare CTRP9 levels in women with Polycystic Ovary Syndrome (PCOS) and without PCOS. Furthermore, to determine the correlation between serum CTRP9 levels and some variety of anthropometric and biochemical parameters.MethodsThe study included 29 PCOS patients and 27 healthy volunteers of the same age and BMI. Body weight, height and waist circumference were assessed. Blood samples were taken for assessment of serum CTRP9 by enzyme-linked immunosorbent assay (ELISA) technique. In addition, blood samples were collected for fasting insulin, glucose, and lipid profiles, and homeostasis model of assessment-insulin resistance (HOMA-IR) values were calculated.ResultsSimilar serum CTRP9 were found in PCOS subjects and controls (8.8 ± 19.9 vs 5.0 ± 7.6 ng/mL). Serum CTRP9 concentration positively correlated with serum LDL-C and total cholesterol in patient group. However, no correlation between CTRP9 and other biochemical and anthropometric variables was found.ConclusionSerum CTRP9 logs of PCOS participants exhibit a positive association with unfavorable lipid profile in this report.