Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
29101 | Journal of Photochemistry and Photobiology A: Chemistry | 2008 | 5 Pages |
Abstract
Irradiation of trazodone at 310 nm in water has been investigated. In addition to the OH-substitution in the chlorobenzene ring a peculiar dimerization of the dihydropyridine moiety leading to a cage-like product was involved in the photo-induced modification of the drug. The photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means. Further support of the structure of the cage-like product was sought by a comparison between the experimental chemical shifts and the values computed at the DFT level.
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Bioengineering
Authors
Marina DellaGreca, Maria Rosaria Iesce, Lucio Previtera, Maria Rubino, Vincenzo Barone, Orlando Crescenzi,