Effect of vitamin D supplementation in type 2 diabetes patients with pulmonary tuberculosis

AimDiabetes and vitamin D deficiency are widely prevalent in India. Studies have proven correlation between low vitamin D levels and pulmonary tuberculosis (PTB) and low vitamin D levels and insulin resistance. We evaluated the effects of vitamin D supplementation on type 2 diabetes mellitus patients with pulmonary tuberculosis (PTB).MethodsForty-five subjects (M:F = 34:11) were screened. Inclusion criteria were age >15 years, newly diagnosed PTB cases with uncontrolled diabetes, serum vitamin D < 20 ng/ml. The patients with vitamin D level < 20 ng/ml were randomly assigned to 2 groups. Group 1 subjects received oral cholecalceferol (60,000 units/week) and calcium carbonate (1 g/day) along with anti tubercular treatment (ATT), while group 2 subjects did not. Sputum was checked at interval of 2 weeks for 12 weeks. Primary end point was time to achieve sputum smear conversion.ResultsFifteen patients having vitamin D > 20 ng/ml were excluded. Age of the patients was 42.9 ± 13.2 years and serum vitamin D levels were 18.4 ± 15.3 ng/ml. Sputum smear conversion was 6 weeks in group 1 versus 8 weeks in group 2 (p = 0.067). Glycated hemoglobin levels reduced from 11.1 ± 1.3 to 7.7 ± 0.9 in group1 versus 10.3 ± 1.2 to 7.8 ± 1.1 (p > 0.1).ConclusionVitamin D can serve as adjuvant treatment of tuberculosis in diabetics with vitamin D deficiency. Further studies are required to validate this observation and define a cut off for vitamin D level to prevent immunological alterations.

► Hypovitaminosis D is linked to occurrence of pulmonary tuberculosis. ► Vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes mellitus. ► Vitamin D may be the missing link between emerging epidemic of tuberculosis and diabetes. ► By virtue of its antiinflammatory effects, vitamin D can serve as an adjuvant treatment of tuberculosis in selected diabetic patients with vitamin D deficiency.