Correlation between indices of kidney function (estimated Glomerular Filteration Rate and proteinuria) and SYNTAX Score in non diabetic chronic kidney disease patients

BackgroundChronic kidney disease (CKD) is highly prevalent with significant morbidity and mortality rates among patients with coronary artery disease (CAD). The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX Score) predicts the outcomes of patients undergoing percutaneous coronary intervention. Our aim was to evaluate the correlation between CKD and severity of coronary artery stenosis by calculating SYNTAX Scores in non diabetic CKD patients.Patients and methodsSYNTAX Score was calculated for 180 non diabetic patients with CKD scheduled for coronary angiography. Serum creatinine, estimated Glomelular Filteration Rate (e-GFR) and 24-h proteinuria prior to Invasive Coronary Angiography (ICA) were assessed in all patients. Patients were divided into two groups according to their e-GFR, group 1 with e-GFR ⩾15 to <30 ml/min per 1.73 m2 and group 2 with e-GFR ⩾30 to <60 ml/min per 1.73 m2.ResultsCoronary arteries lesions complexity increased progressively with decreasing kidney function as there was significant negative correlation between e-GFR and SYNTAX Score (r = −0.5, P = 0.0004) and significant positive correlation between 24-h proteinuria and SYNTAX Score (r = 0.6, p = 0.0001).ConclusionEstimated glomerular filtration rate and 24-h proteinuria were predictors of higher SYNTAX Scores.