Consecuencias clínicas de la fibrosis miocárdica en la cardiopatía hipertensiva

Changes in the composition of cardiac tissue develop in arterial hypertension and lead to structural remodeling of the myocardium; Structural remodeling is the consequence of a number of pathologic processes; mediated by mechanical; neurohormonal and cytokines factors that occur in the cardiomyocyte and the non-cardiomyocyte compartments of the heart; One of these processes is related to the disruption of the equilibrium between the synthesis and degradation of collagen type I and III molecules; This causes an excessive accumulation of collagen type I and III fibers in the interstitium and the perivascular regions of the myocardium; The clinical relevance of myocardial fibrosis is that it might contribute to increased cardiac risk of patients with hypertensive heart disease; This revision focuses on the clinical consequences of hypertensive myocardial fibrosis; In addition; non-invasive methods for the diagnosis of cardiac fibrosis and the therapeutic strategies aimed at promoting its reduction will be also considered