Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
29274 | Journal of Photochemistry and Photobiology A: Chemistry | 2007 | 8 Pages |
Abstract
Fluvastatin is easily transformed in water by solar irradiation. One day-light exposure induces a complete degradation of the drug and formation of a mixture of products. Different chromatographic processes led to the isolation of dihydrobenzocarbazole, benzocarbazole, azonane-2,7-dione and spiro[4.4]azononane derivatives. Structures of photoproducts were elucidated by spectroscopic means. Photocyclization and photooxygenation are the main reactions involved in the formation of the observed products.
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Authors
Flavio Cermola, Marina DellaGreca, Maria Rosaria Iesce, Sara Montanaro, Lucio Previtera, Fabio Temussi, Marcello Brigante,