Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2951827 | Journal of the American College of Cardiology | 2006 | 7 Pages |
ObjectivesWe present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO).BackgroundPulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal.MethodsData from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]).ResultsThe patients’ symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = −0.667, p < 0.05). A CSI ≥75% correlated well with low lung perfusion (<25%; r = −0.854, p < 0.01). Patients with a CSI ≥75% appeared to improve mostly when early (r = −0.497) and repeat dilation/stenting (r = 0.0765) were performed.ConclusionsPatients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.