Increased Myosin Heavy Chain-β With Atrial Expression of Ventricular Light Chain-2 in Canine Cardiomyopathy

The cardiac myosin isoform shifts in this study were similar to those observed in end-stage human heart failure and more severe than those reported in less prolonged pacing models, supporting the use of this model for further study of end-stage human heart failure. The observation of consistent differences between sampling sites, especially LA versus LAA, indicates the need for rigorous sampling consistency in future studies.