Article ID Journal Published Year Pages File Type
2963133 Journal of Cardiology 2012 7 Pages PDF
Abstract

BackgroundAlmost all data on drug-eluting stents (DES) fracture have been derived from initial platform of first-generation DES such as Cypher Bx® (CBX) and Taxus Express®. However, incidence and clinical impact of fracture of newer DES platforms (including Cypher Select®, Taxus® Liberté™, Endeavor®, and Xience™ V) that have been used widely in current clinical practice have not yet been studied.Methods and resultsWe analyzed data of 1518 lesions treated with the newer DES platforms in patients who underwent follow-up coronary angiography and compared the results with those of 622 lesions treated with the CBX. The group of newer DES platforms showed significantly lower incidence of stent fracture (SF) than the CBX group (1.25% vs. 5.8%, p < 0.001). Binary restenosis (42.1% vs. 6.6%, p < 0.001) and target lesion revascularization (TLR) (47.3% vs. 6.2%, p < 0.001) related to SF in the newer DES platforms’ group were significantly higher than those not related to SF. Notably, SF-related binary restenosis (42.1% vs. 36.1%, p = 0.52) and TLR (47.3% vs. 41.6%, p = 0.2) were similar between the newer DES platforms’ group and the CBX group. On multivariable logistic regression analysis, lesion angulation >45° (odds ratio [OR]: 7.6; 95% confidence interval [CI]: 2.2–26.31), RCA stenting (OR: 5.14; 95% CI: 1.62–16.3) and total stent length (OR: 1.18; 95% CI: 1.03–1.33) were identified as independent predictors for fracture of the newer DES platforms, while closed-cell design stent (Cypher Select®) was not.ConclusionsAlthough implantation of the newer DES platforms might reduce the occurrence of SF compared with the CBX, SF-related binary restenosis and TLR remain similarly high. And to predict SF in the newer DES platforms’ era, lesion characteristics on index procedure are more important than implanted stent design.

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