| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 29875 | Journal of Photochemistry and Photobiology B: Biology | 2016 | 7 Pages |
Abstract
•TC dyes interact with HSA as indicated by UV–Vis and fluorescence measurements.•TC1 and TC2 result in efficient 1O2 generators.•TC1 and TC2 cause a rapid intracellular ROS release following light beam exposure.•TC1 compound has a considerable photo-toxic effect in human fibrosarcoma cells.
The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effects which can avoid chemo-resistance pathways. The potential photodynamic activity of two fluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Francesca Baldassarre, Federica Foglietta, Viviana Vergaro, Nadia Barbero, Agostina L. Capodilupo, Loredana Serpe, Sonja Visentin, Antonio Tepore, Giuseppe Ciccarella,