Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3015984 | Revista Española de Cardiología | 2006 | 4 Pages |
Abstract
Natriuretic peptides are extremely useful in the diagnosis and prognosis of patients with heart failure. However, it is not clear whether their values are stable. We carried out a prospective study of 30 consecutive ambulatory patients (mean age, 62.6 [12.2] years) with stable systolic heart failure, as determined by the 6- minute walk test, who were in New York Heart Association class II or III and who had a left ventricular ejection fraction <30% (mean ejection fraction, 24.2% [6.68%]). At baseline, the mean N-terminal pro-brain natriuretic peptide (NT-proBNP) level and the mean distance walked in 6 minutes were 2237.3Â pg/mL and 348.26Â m, respectively. At 3-month follow-up, the corresponding values were 2096.2Â pg/mL and 372.05Â m, respectively. No significant difference was observed in NT-proBNP level or in distance walked in 6 minutes between baseline and 3 months (P=.8). Overall, there was a good correlation (r=0.94; P<.001) between the plasma NT-proBNP level at baseline and at 3 months in patients with stable chronic heart failure due to systolic dysfunction in New York Heart Association class II or III.
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Authors
Manuel F. Jiménez-Navarro, MarÃa A. Fernández-Moyano, Antonio DomÃnguez-Franco, Juan J. Gómez-Doblas, Encarnación Molero, Gemma Gómez-Hernández, Miguel Morell, Eduardo de Teresa-Galván,