Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3030898 | Trends in Cardiovascular Medicine | 2014 | 6 Pages |
Abstract
The Brugada syndrome is a rare but well-defined cause of sudden cardiac death. The key underlying abnormality is a decrease in net depolarising current due to a genetic defect, though recent evidence also implicates structural abnormalities in some patients. Diagnosis requires a Brugada-type ECG as well as typical clinical features: such clinical considerations are currently key in guiding risk stratification and hence management. Whilst pharmacological therapies are under investigation, the only intervention with a robust evidence base remains insertion of an implantable cardioverter defibrillator. Further research will be required to allow more effective risk stratification and hence more rational therapy.
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Authors
Meghavi Mashar, Andrew J. Kwok, Richard Pinder, Ian Sabir,