| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3031164 | Trends in Cardiovascular Medicine | 2008 | 7 Pages |
Abstract
Endothelium lining the coronary vasculature and the heart chambers is a dynamic sensor that serves a variety of functions including bidirectional communications with cardiac myocytes. Among endothelium-released factors, nitric oxide exerts multifactorial effects on various cell types in the heart and may play a role in growth of the vasculature and myocardial hypertrophy. This review summarizes new data regarding the endothelium-to-myocyte signaling focusing on its role in regulation of cardiac hypertrophy through a nitric-oxide-mediated paracrine signal.
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Authors
Daniela Tirziu, Michael Simons,