| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3031550 | Trends in Cardiovascular Medicine | 2006 | 5 Pages |
Abstract
Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.
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Authors
Martin Spiecker, JamesK. Liao,