| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3031778 | Trends in Cardiovascular Medicine | 2011 | 6 Pages |
Abstract
Half of heart failure patients have diastolic heart failure, which has no effective treatments. Several studies indicate a role for ω-3 polyunsaturated fatty acids (PUFAs) in heart failure. Recent studies suggest that ω-3 PUFAs inhibit cardiac fibrosis and attenuate diastolic dysfunction. This opens up possible new avenues for treatment of diastolic heart failure. In this review, we focus on the antifibrotic effects of ω-3 PUFAs in heart and the underlying cellular and molecular mechanisms.
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Authors
Dajun Wang, John O'Horo,