| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3031873 | Trends in Cardiovascular Medicine | 2008 | 9 Pages |
Abstract
Long-QT syndromes (LQTSs) have been described in all ages and are a significant cause of cardiovascular mortality, especially in structurally normal hearts. Abnormalities in transmembrane ion conduction channels and structural proteins produce these clinical syndromes, labeled LQT1-LQT12; however, genotype-positive patients still represent only about 70% of LQTSs. Future research will determine the etiology of the remaining cases, further risk-stratify the known genetic defects, improve current treatment options for these syndromes, and uncover novel therapies.
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Authors
Gregory Webster, Charles I. Berul,