Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3063968 | Journal of Neuroimmunology | 2014 | 13 Pages |
Abstract
As the immune cells of the brain, microglia are crucial for the maintenance of brain function. The aims of the present study were to determine whether and how annexin-1 is able to affect microglial phenotype and migration in the lesion microenvironment. In the current experiment, we enhanced the interaction between annexin-1 and formyl peptide receptors in microglia and analyzed the function. We found that annexin-1 could polarize microglia to a beneficial phenotype and promote microglial migration to protect neurons from ischemia-like injury, and the annexin-1-mediated neuroprotective effect was dependent on the release of glutamate and ATP from the injured neurons.
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Authors
Zhen Zhao Luo, Yan Gao, Ning Sun, Yin Zhao, Jing Wang, Bo Tian, Jing Shi,