Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3063992 | Journal of Neuroimmunology | 2014 | 6 Pages |
Abstract
We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
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Authors
Francesca Notturno, Tiziana Di Febo, Nobuhiro Yuki, Blanca M. Fernandez Rodriguez, Davide Corti, Eduardo Nobile-Orazio, Marinella Carpo, Angelo De Lauretis, Antonino Uncini,