| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3064277 | Journal of Neuroimmunology | 2013 | 8 Pages |
•Inflammation is a component of glioma microenvironment.•The long pentraxin PTX3 is a candidate marker of inflammation.•PTX3 is produced in human gliomas by tumoral cells and CD68 positive macrophages.•PTX3 levels are correlated with the tumour grade and histopathological diagnosis.•PTX3 may represent a new marker of cancer-related inflammation and glioma behaviour.
Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation.In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
