Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064305 | Journal of Neuroimmunology | 2012 | 11 Pages |
Abstract
Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, leading to the generation of CD28− T-cells. Our aim was to examine whether CD4+CD28− T-cells were enriched in MS patients, and characterize the phenotype of this subset in MS patients and healthy controls (HC).All these changes could provide these CD4+CD28− T-cell characteristics that might be involved in the pathogenesis of MS, turning this T-cell subset into a potential target for future therapeutic strategies.
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Authors
María Jesús Pinto-Medel, Juan Antonio García-León, Begoña Oliver-Martos, Carlos López-Gómez, Gloria Luque, Carlos Arnáiz-Urrutia, Teresa Órpez, Carmen Marín-Bañasco, Oscar Fernández, Laura Leyva,