Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064419 | Journal of Neuroimmunology | 2011 | 6 Pages |
Abstract
High occurrence of measles, rubella and varicella zoster antibodies has been used as a biomarker for MS (the MRZ test). We analyzed measles antibody titres with respect to measles infection/measles vaccination status in 166 patients with MS or clinically isolated syndrome. Fifty blood donors served as controls. Measles vaccination yielded CSF measles antibodies in fewer patients (62%) than measles infection did (87%, p = 0.001) and yielded lower measles titres in both serum and CSF (p < 0.001). Controls had lower CSF measles titres than patients with measles vaccination alone (p < 0.001). Childhood vaccinations probably reduce the sensitivity of the MRZ diagnostic test for MS.
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Authors
Cecilia Ahlgren, Anders Odén, Sara Haghighi, Oluf Andersen, Tomas Bergström, Jan Lycke,