Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064438 | Journal of Neuroimmunology | 2011 | 4 Pages |
Abstract
Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients.
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Authors
S. Malhotra, C. Morcillo-Suárez, D. Brassat, R. Goertsches, J. Lechner-Scott, E. Urcelay, O. Fernández, J. Drulovic, A. García-Merino, F. Martinelli Boneschi, A. Chan, K. Vandenbroeck, A. Navarro, M.F. Bustamante, J. Río, D.A. Akkad, G. Giacalone,