Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064446 | Journal of Neuroimmunology | 2011 | 7 Pages |
Abstract
Earlier studies showed that donor T cells that initiated a murine adoptive EAE persisted in the CNS of the recipients throughout the subsequent relapsing cycles. To clarify the functions of the persistent donor T cells in EAE relapsing disease, anti-Thy-1 antibodies were used to deplete these cells. Results showed that such treatment abrogated subsequent relapsing cycles in these animals. In addition, it was evident that a shift in cytokine profile occurred during acute and relapsing disease phases. These results unambiguously support the appropriateness of targeting T cells with specificity for the priming antigen in design of therapeutic approaches for MS.
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Authors
Jinzhu Li, Xiaoqing Zhao, Hui-Wen Hao, Michael K. Shaw, Harley Y. Tse,