Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064480 | Journal of Neuroimmunology | 2010 | 10 Pages |
Abstract
In this study, the role of NF-κB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-κB1−/− mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8+ T cells and IFN-γ production, while accessory cell function appeared intact in NF-κB1−/− mice. Consistent with these findings, T cell transfer studies revealed that NF-κB1−/− T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-κB1 in T cell-mediated immunity to Toxoplasmagondii.
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Authors
Tajie H. Harris, Emma H. Wilson, Elia D. Tait, Marie Buckley, Sagi Shapira, Jorge Caamano, David Artis, Christopher A. Hunter,