Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064531 | Journal of Neuroimmunology | 2010 | 12 Pages |
Abstract
Massive programmed cell death (PCD) of developing chick embryo motoneurons (MNs) occurs in a well defined temporal and spatial sequence between embryonic day (E) 6 and E10. We have found that, when administered in ovo, either circulating immunoglobulins G (IgGs) or cerebrospinal fluid from patients with MN disease can rescue a significant number of chick embryo MNs from normally occurring PCD. An increase of branching of intramuscular nerves was also observed that may account for the rescuing effects of pathologic IgGs. Proteomic analysis and further analysis by ELISA indicated that these effects may be mediated by the interaction of circulating human immunoglobulins with proteins of the semaphorin family.
Keywords
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Immunology
Authors
Sara Hernández, Laura Texidó, Jordi Calderó, Dolors Ciutat, Lídia Piedrafita, Anna Casanovas, Joan Blasi, Carles Solsona, Mònica Povedano, Ricardo Rojas, Isabel Illa, James Caress, David Prevette, Ronald W. Oppenheim, Carol Milligan, Josep E. Esquerda,