Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064605 | Journal of Neuroimmunology | 2010 | 7 Pages |
Abstract
To investigate the role of C5a generated on complement activation in brain, the lupus model, MRL/lpr mice were treated with C5a receptor(R) antagonist (ant). Neutrophil infiltration, ICAM, TNF-α and iNOS mRNA expression, neuronal apoptosis and the expression of p-JNK, pSTAT1 and p-Erk were reduced and p-Akt increased on C5aR inhibition in MRL/lpr brains. MRL/lpr serum caused increased apoptosis in neurons showing that lupus had a direct effect on these cells. C5aRant pretreatment prevented the lupus serum induced loss of neuronal cells. Our findings demonstrate for the first time that C5a/C5aR signaling plays an important role in the pathogenesis of CNS lupus.
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Authors
Alexander Jacob, Bradley Hack, Tao Bai, James R. Brorson, Richard J. Quigg, Jessy J. Alexander,