| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3064608 | Journal of Neuroimmunology | 2010 | 5 Pages |
Abstract
Neuromyelitis optica (NMO) is a devastating neuroinflammatory disorder that specifically targets the spinal cord and optic nerves. Aquaporin-4 (AQP4) is the target of the NMO-IgG biomarker. AQP4 is expressed as two isoforms: M1 and M23, which have different functions in the central nervous system (CNS). We characterized the expression pattern of these AQP4 isoform mRNAs in humans and found a pattern of AQP4 expression that correlates with NMO disease localization. The ratio of M1:M23 mRNA is highest in the optic nerve and spinal cord, followed by brainstem, then the cerebral and cerebellar cortices.
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Authors
Harleen Saini, Gregory Fernandez, Douglas Kerr, Michael Levy,