| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3064661 | Journal of Neuroimmunology | 2010 | 6 Pages |
Abstract
The association between anti-triosephosphate isomerase (TPI) antibodies and MRL/MpJ-Faslpr (MRL/lpr) mice was examined. We found that serum anti-TPI antibody levels in MRL/lpr mice, measured by enzyme-linked immunosorbent assay, were significantly higher than that of age-matched Balb/c mice and NZB/WF1 mice. Anti-TPI antibodies were detected in serum and cerebrospinal fluid in MRL/lpr mice by Western blotting. Inoculation of anti-TPI monoclonal antibody-producing hybridoma into the brain of Balb/c mice resulted in immunoglobulin deposition in the regions near the ventricles, hippocampus, and choroid plexus. Anti-TPI antibodies may play a role in the etiology of brain damage and behavioral deficits in MRL/lpr mice.
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Authors
Shuzo Sato, Hiroshi Watanabe, Kiori Shio, Hiroko Kobayashi, Hiromasa Ohira,