| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3064663 | Journal of Neuroimmunology | 2010 | 10 Pages |
Abstract
Oxidized phospholipids (Ox-PLs) are generated in abundance at sites of inflammation. Recent studies have indicated that Ox-PLs may also exhibit anti-inflammatory activities. In this study, we investigated the beneficial effect of VB-201, a pure synthetic Ox-PL analog that we synthesized, on the development of a central nervous system (CNS) autoimmune inflammatory disease, in vivo. Oral administration of VB-201 ameliorated the severity of experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) peptide MOG35-55, and restrained the encephalogenicity of MOG35-55-specific T-cells. Our data presents a novel prospect for the role of Ox-PL analogs in CNS inflammatory diseases.
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Authors
Itzhak Mendel, Anat Shoham, Oshrat Propheta-Meiran, Eti Ishai, Gideon Halperin, Erez Feige, Eyal Breitbart,