Article ID Journal Published Year Pages File Type
3064695 Journal of Neuroimmunology 2010 5 Pages PDF
Abstract

Multiple Sclerosis (MS) is a genetically complex immune mediated, demyelinating disease of the central nervous system. To date no genetic variants have been unambiguously linked to disease severity. We have conducted a genome wide screen, using Affymetrix Genechip® 500K technology, for severity in 1040 MS patients. Two markers within MGAT5, a gene coding for a glycosylation enzyme, were found to be significantly associated with outcome in the screening as well as in an independent population (combined p-values: 2.8 × 10− 6 and 1.5 × 10− 7).

Related Topics
Life Sciences Immunology and Microbiology Immunology
Authors
, , , , , , , , , ,