Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064740 | Journal of Neuroimmunology | 2010 | 10 Pages |
Abstract
Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner. We evaluated effects of RTL401 (I-As α1β1 + PLP-139-151) on splenocytes from SJL/J mice with EAE to study RTL-T cell tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, through RTL-MHC-α1β1 moiety. RTL binding reduced CD11b expression on splenic macrophages/DC, and RTL401-conditioned macrophages/DC, not B cells, inhibited T cell activation. Reduced ability of RTL- incubated splenocytes to transfer EAE was likely mediated through macrophages/DC, since B cells were unnecessary for RTL treatment of EAE. These results demonstrate a novel pathway of T cell regulation by RTL-bound APCs.
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Authors
Sushmita Sinha, Lisa Miller, Sandhya Subramanian, Owen J.T. McCarty, Thomas Proctor, Roberto Meza-Romero, Jianya Huan, Gregory G. Burrows, Arthur A. Vandenbark, Halina Offner,