Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064770 | Journal of Neuroimmunology | 2010 | 9 Pages |
Abstract
This work shows a comparative study on the effects of chronic mild stress upon learning and memory and immunity, in BALB/c and C57BL/6 mice. Stressed BALB/c, but not C57Bl/6 mice, showed a poor learning performance, morphological alterations in the hippocampus with an increase in oxidative stress. A correlation between poor memory performance and the increase of the Th2/Th1 balance was found. Our results suggest that vulnerability to cognitive deficit associated with stress exposition could be related to a differential regulation of Th1/Th2 cytokine balance, suggesting a better learning performance for individuals that produce Th1 type cytokine after stress exposition.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
M.L. Palumbo, M.C. Canzobre, C.G. Pascuan, H. Ríos, M. Wald, A.M. Genaro,