Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064787 | Journal of Neuroimmunology | 2010 | 6 Pages |
Abstract
Clonally expanded plasma cells (cePC) and oligoclonal IgG (oligoclonal bands, OCB) in the cerebrospinal fluid (CSF) suggest an involvement of B cell mechanisms in autoimmune CNS demyelination. Due to their CSF-restricted occurrence, OCB are commonly believed to be the products of B cells inside the borders of the blood brain barrier. A comparison of CSF cell Ig transcriptomes and CSF-Ig proteomes recently demonstrated, that in multiple sclerosis patients CSF cells are the origin of CSF immunoglobulins. We expand these findings by applying anti-idiotypic antibodies to detect specific heavy chain CDR3 idiotopes of cePC-produced antibodies amongst OCB in the CSF of a patient each with MS and acute disseminated encephalomyelitis.
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Authors
Hans-Christian von Büdingen, Monica Gulati, Sandra Kuenzle, Katja Fischer, Tobias A. Rupprecht, Norbert Goebels,