| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3064834 | Journal of Neuroimmunology | 2010 | 4 Pages |
Abstract
We identified the autoantibody against phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme, in sera from multiple sclerosis (MS) patients by proteomics-based analysis. We further searched this autoantibody in sera from patients with other neurological diseases. The prevalence of the anti-PGAM1 antibody is much higher in patients with MS and neuromyelitis optica (NMO) than in those with other neurological diseases and in healthy controls. It was reported that the anti-PGAM1 antibody is frequently detected in patients with autoimmune hepatitis (AIH). Results of our study suggest that the anti-PGAM1 antibody is not only a marker of AIH but also a nonspecific marker of central nervous system autoimmune diseases.
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Authors
A. Kimura, T. Sakurai, A. Koumura, M. Yamada, Y. Hayashi, Y. Tanaka, I. Hozumi, R. Tanaka, M. Takemura, M. Seishima, T. Inuzuka,