Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064922 | Journal of Neuroimmunology | 2008 | 5 Pages |
Abstract
We showed previously and we confirm here that macrophages from three mouse strains are differentially sensitive to the inhibition of expression of key inflammatory proteins (iNOS-II, IL-1β) by dexamethasone, a specific glucocorticoid receptor agonist (C57BL/6 > DBA/2 > BALB/c). Here we show that aldosterone (a specific mineralocorticoid agonist) has no effect on iNOS-II or IL-1β expression in macrophages from these mouse strains but decreases IL-1ra expression, with small inter-strain differences. This mechanism may be involved in the pro-inflammatory effect of this hormone. Concanavalin A-stimulated lymphocytes proliferation is also differentially sensitive to dexamethasone according to the strain, but insensitive to aldosterone.
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Authors
H. Harizi, P. Mormède, J.-B Corcuff,