Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064954 | Journal of Neuroimmunology | 2009 | 8 Pages |
Abstract
Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~ 16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice appear to show reactivity prior to clinical diagnosis of SCLC. This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies.
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Authors
Meleeneh Kazarian, Joaquim Calbo, Natalie Proost, Catherine L. Carpenter, Anton Berns, Ite A. Laird-Offringa,