Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3064986 | Journal of Neuroimmunology | 2009 | 8 Pages |
Abstract
We identified a unique antibody gene mutation pattern (i.e. “signature”) in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
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Authors
Elizabeth M. Cameron, Sade Spencer, Jonathan Lazarini, Christopher T. Harp, E. Sally Ward, Mark Burgoon, Gregory P. Owens, Michael K. Racke, Jeffrey L. Bennett, Elliot M. Frohman, Nancy L. Monson,