Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population

Single nucleotide polymorphisms in human MMP genes, including MMP1 (− 1637 1G > 2G), MMP3 (− 1612 5A > 6A), MMP9 (− 1562 C > T), and MMP12 (− 82 A > G), and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found among carriers of at least one T allele of MMP9 − 1562 C > T (OR, 1.7; p = 0.0030) and one G allele of MMP12 − 82 A > G (OR, 3.9; p < 0.00001). Additionally, an association between MMP9 genotype and MMP-9 levels in peripheral blood was detected. Our results suggest that MMP9 − 1562 C > T and MMP12 − 82 A > G polymorphisms affect susceptibility to multiple sclerosis.