Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065071 | Journal of Neuroimmunology | 2009 | 9 Pages |
Abstract
Interlukin-17 (IL-17) is active in a variety of brain injuries, including ischemia. The objective of this study was to test the hypothesis that IL-17 potentiates neuronal injury after stroke. Increased expression of IL-17 and IL-17 receptor (IL-17R) in serum and cortex was evaluated by ELISA, RT–PCR and immunohistochemistry. In the in vitro model of oxygen–glucose deprivation (OGD), IL-17 showed a dose-dependent effect in promoting neuronal injury through IL-17-IL-17R combination which can be blocked by IL-17R/Fc chimera. Our results demonstrated the up-regulation of IL-17 and IL-17R following permanent middle cerebral artery occlusion and suggested that they contributed to stroke outcome.
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Authors
Dan-dan Wang, Yan-feng Zhao, Guang-you Wang, Bo Sun, Qing-fei Kong, Kai Zhao, Yao Zhang, Jing-hua Wang, Yu-mei Liu, Li-li Mu, De-sheng Wang, Hu-lun Li,