Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065101 | Journal of Neuroimmunology | 2008 | 7 Pages |
Abstract
To understand developmental mechanisms of effector B-cells in the hyperplastic MG thymus, we have evaluated immunological roles of IL-2 and the 100-kDa haemopoietic biglycan, because the number of their producers increases pathologically there. When these two factors were added to an immune system together, the number of antibody-producing cells was markedly increased in a synergistic fashion. Further, IL-2 and the conditioned medium of myoid cells induced immunoglobulin isotype switches, suggesting that new B-cell stimulatory microenvironments were generated in the hyperplastic thymus. In relation to this, we also discuss a new biological feature, an immunomodulator, of conventional biglycan and decorin.
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Authors
Aiko Kikuchi, Hiroshi Tomoyasu, Isao Kamo,