Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065193 | Journal of Neuroimmunology | 2009 | 11 Pages |
Abstract
Accumulating evidence suggests that autoimmunity against neuronal proteins is important for MS pathogenesis. We have characterized T- and B-cell responses associated with experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats with recombinant β-Synuclein (βSync), a neuronal component. The encephalitogenic βSync-specific T cells recognize a single immunodominant region with an epitope delineated at amino acids 97-105; B-cell specificity is more widespread, albeit directed mostly to the C-terminus of βSync. Most interestingly, βSync-induced autoimmune T- and B-cell responses spread not only to other neuronal antigens but also to myelin encephalitogens, raising the possibility that anti-neuronal immune attacks could also result in demyelination.
Keywords
MOGMOBPautoantibodiesMBPIPTGNFLGADTMBLNCEAEOSPAntigens/peptides/epitopesexperimental autoimmune encephalomyelitistetramethylbenzidineRodentautoimmunityT cellslymph node cellsAlpha synucleinCyclophosphamidestimulation indexMultiple sclerosisneurofilamentMyelin basic proteinmyelin oligodendrocyte glycoprotein
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Authors
Neta Kela-Madar, Nicole Kerlero de Rosbo, Ayal Ronen, Felix Mor, Avraham Ben-Nun,