Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065194 | Journal of Neuroimmunology | 2009 | 10 Pages |
Abstract
An unexpectedly prominent aspect of murine experimental autoimmune encephalomyelitis is pre-onset astrocyte reactivity. Further examination of this phenomenon in the spinal cord demonstrates that grey matter, as well as white matter astrocytes, change their morphology and cell density from the earliest disease manifestation. Comparison of the two compartments reveals that, whereas white matter changes are rostro-caudally consistent, grey matter reactivity is spatially restricted and of varying amplitude between spinal cord levels. These data strongly suggest that in neuroinflammation early, cross-compartmental recruitment of astrocytes occurs, but with different expression patterns.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Hong Pham, Anton A. Ramp, Nectarios Klonis, Sze Woei Ng, Armelle Klopstein, Margaret M. Ayers, Jacqueline M. Orian,