Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065242 | Journal of Neuroimmunology | 2009 | 7 Pages |
Abstract
The role of IL-15 in T cell survival was examined during chronic CNS coronavirus infection. Similar numbers of virus-specific CD8+ T cells were retained in the CNS of IL-15â/â and wt mice, consistent with loss of IL-2/15 receptor (CD122) expression. IL-15 deficiency also had no affect on IL-7 receptor (CD127) expression, Bcl-2 upregulation, granzyme B expression, or IFN-γ secretion in CNS persisting CD8+ T cells. Furthermore, CD8+ T cell division in the CNS was reduced compared to spleen. CD8+ T cells in the persistently infected CNS are thus characterized by IL-15 independent, low level proliferation and an activated/memory phenotype.
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Authors
Jun Zuo, Stephen A. Stohlman, Gabriel I. Parra, Cornelia C. Bergmann,