Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065292 | Journal of Neuroimmunology | 2008 | 11 Pages |
Abstract
One concern in the use of transplantation of non-hematopoietic stem cells from human umbilical cord blood (CB-nHSCs) is the possibility of rejection by the host's immune system. This study shows that both CB-nHSCs and their progenies after passaging, neuronal differentiation or IFN-γ treatment have no significant effects on proliferation of xenogenic T lymphocytes. CB-nHSCs transplanted into the striatum of SD rat are shown to induce a lower level of CD4 and CD8 expression in the brain and in the peripheral blood and to survive better in the brain than SH-SY5Y cells. The results indicate that both undifferentiated and differentiated CB-nHSCs all have weak immunogenicity.
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Authors
Fengqing Ji, Yi Wang, Haimei Sun, Juan Du, Huanying Zhao, Danni Wang, Qunyuan Xu, Deyi Duan, Hui Yang,