Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065323 | Journal of Neuroimmunology | 2007 | 14 Pages |
Abstract
Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Juliana Pérez Laspiur, Eric R. Anderson, Pawel Ciborowski, Valerie Wojna, Wojciech Rozek, Fenghai Duan, Raul Mayo, Elaine Rodríguez, Marinés Plaud-Valentín, José Rodríguez-Orengo, Howard E. Gendelman, Loyda M. Meléndez,