Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065328 | Journal of Neuroimmunology | 2007 | 6 Pages |
Abstract
The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. However, we found a potent MOG-specific cellular and humoral immune response. Interestingly, MOG-specific cellular immune response rapidly decreased, paralleling the improvement of clinical condition. In conclusion, this detailed study shows that acute EBV infection can trigger a potent auto-inflammatory response in the CNS, without evidence of an overt infection.
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Authors
Samantha Jilek, Jens Kuhle, Pascal Meylan, Marc D. Reichhart, Giuseppe Pantaleo, Renaud A. Du Pasquier,