Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065360 | Journal of Neuroimmunology | 2008 | 12 Pages |
Abstract
Natalizumab, the most recently approved treatment for relapsing multiple sclerosis (MS) exerts its action through binding to α4 integrins. We studied longitudinally gene expression profiles in peripheral blood of MS patients, treated with natalizumab for more than 2 years. The majority of altered genes relates to immune response, signal transduction, adhesion and metabolism. Not only gene expression relevant for T lymphocytes was altered, but also genes regulating B-lymphocyte, neutrophil and erythrocyte functions. Understanding these different gene effects and their interrelationships will provide more insights into additional mechanisms of action of natalizumab and possibly allow better prediction of adverse events.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Raija L.P. Lindberg, Lutz Achtnichts, Francine Hoffmann, Jens Kuhle, Ludwig Kappos,