Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065385 | Journal of Neuroimmunology | 2008 | 11 Pages |
Abstract
Anorexia–cachexia syndrome is a very common symptom observed in individuals affected by chronic inflammatory diseases. The present study was designed to address the possible involvement of the inducible microsomal prostaglandin E synthase-1 (mPGES-1) in the hypopaghia observed during these pathological states. To this end, we used a model of cancer-induced anorexia and we report here that despite the absence of up-regulation of the mPGES-1 enzyme within the brain during anorexia–cachexia syndrome, mPGES-1 knock-out mice exhibit resistance to tumor-induced anorexia and maintain their body mass.
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Authors
E. Pecchi, M. Dallaporta, A. Jean, S. Thirion, J.D. Troadec,