| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3065406 | Journal of Neuroimmunology | 2008 | 7 Pages |
Abstract
CGRP significantly stimulated migration of non-activated and anti-CD3 activated T lymphocytes into a collagen matrix when present inside the collagen, whereas somatostatin-14, NPY, substance P, VIP, β-endorphin and metenkephalin had no or little effect. The CGRP antagonist CGRP 8–37 abrogated the CGRP-induced cell infiltration. Virtually all migrating cells were CD3+ (> 96%) and CGRP did not stimulate B-cell migration. The migration capacity showed no selective relationship to the expression of CD4+, CD8+, CD45RO+ (memory), or CD45RA+ (naive) T cell markers indicating that the regulation of T cell migration is distinct from that of the major T cell phenotypes.
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Authors
Toomas Talme, Zhiwen Liu, Karl-Gösta Sundqvist,