| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3065436 | Journal of Neuroimmunology | 2006 | 4 Pages |
Abstract
Affinity maturation has previously been shown with assays for total IgG for specific antigens using the technique of competition by chaotropic ions. We have extended this technique to individual clones and followed the maturation of clones during the course of herpes encephalitis. This has important implications for our understanding of the pathogenesis of multiple sclerosis.
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Authors
Gavin Giovannoni, Miles D. Chapman, Edward J. Thompson,